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    2. 醫學部坐倚珞珈山,環繞東湖水,綠樹成蔭,花香流溢。學部源于1943年成立的湖北省省立醫學院,現在是武漢大學六大學部之一。 學部含基礎醫學院、第一臨床學院、第二臨床學院、口腔醫學院、藥學院、健康學院、職業技術學院...

      地址: 湖北省武漢市武昌區東湖路115號
      電話:027-68759364
      中國科學院院士: 鄧子新、舒紅兵
      國家級教學名師: 樊明文、邊專
      國家杰出青年基金獲得者: 鄧子新、舒紅兵、章曉聯、李紅良、卿國良
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      醫學部8號樓會議室使用通知單

      姓名:舒紅兵

      單位:武漢大學醫學研究院

      職稱:教授、中國科學院院士、副校長、 院長

      郵箱:shuh@whu.edu.cn

      聯系電話:027-68755692

      研究方向:天然免疫與炎癥反應機制








      代表性論著:

      1. Shu HB,Agranoff A, Nabel EG, Leung K, Neish AS, Collins , Nabel GJ* (1993).Differential regulation of VCAM-1 gene expression by specific NF-kB subunits in endothelial and epithelial cells.Mol Cell Biol13:6283-6289.

      2. Shu HB, Li Z, Palacios MJ, Li Q, Joshi HC* (1995). A transient association of g-tubulin at the midbody is required for the completion of cytokinesis during the mammalian cell division.J Cell Sci108: 2955-2962.

      3. Shu HB, Joshi HC* (1995). g-Tubulin can both neacleate microtubule assembly and self-assemble into tubular structures in mammalian cells.J Cell Biol130:1137-1147.

      4. Hsu H,Shu HB,Pan MG, Goeddel DV* (1996). TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor-1 signal transduction pathways.Cell84:299-308.

      5. Shu HB,Takeuchi M, Goeddel DV* (1996). The TNF receptor 2 signal transducers TRAF2 and c-IAP1 are components of the TNF receptor 1 signaling complex.P Natl Acad Sci USA93:13973-13978.

      6.Shu HB,Halpins DR, Goeddel DV* (1997). Casperis a FADD and Caspase-related Inducer of Apoptosis.Immunity6:751-763.

      7. Yeh WC, Pompa JL, McCurrach ME,Shu HB,Elia AJ, Shahinian A, Ng M, Wajegam A, Mithchell K, El-Deiry WS, Lowe SW, Goeddel DV M,ak TW* (1998). FADD: essential for embryonic development and signaling from some, but not all, inducers of apoptosis.Science279:1954-1958.

      8.Shu HB*, Hu WH, Johnson H (1999). TALL-1 is a novel member of the TNF family that is downregulated by mitogens.J Leukocyte Biol65:680-683.

      9. Hu WH, Johnson H,Shu HB*(1999). TRAIL signal NF-kB and JNK activation and apoptosis through distinct pathways. J Biol Chem274:30603-30610.

      10. Hu WH, Johnson H,Shu HB* (2000). Activation of NF-kB by FADD, Casper and Caspase-8.J Biol Chem275:10838-10844.

      11. Shu HB*,Johnson H (2000). BCMA is a receptor for the TNF family member TALL-1.P Natl Acad Sci USA97:9156-9161.

      12. Chen D, Li X, Zhai Z,Shu HB*(2002).A novel zinc finger protein interacts with RIP and inhibits TNF- and IL-1-induced NF-kB activation.J Biol Chem.277:15985-15991.

      13. Liu Y, Xu L, Opalka N, Kappler J,Shu HB, Zhang G* (2002). Crystal structure of sTALL-1 reveals a virus-like assembly of TNF family ligands.Cell108: 383-394.

      14. Wu M, Xu L, Li X, Zhai Z ,Shu HB* (2002). AMID, an AIF homologous mitochondrion-associated protein, induces caspase-independent apoptosis. J Biol Chem277:25617-25623.

      15. Xu L,Shu HB*(2002). TRAF3 is associated with BAFF-R and negatively regulates BAFF-R-mediated NF-kB activation and IL10 production.J Immunol169: 6883-6889.

      16. Chen D, Xu LG, Chen L, Li L, Zhai Z, andShu HB*(2003). NIK is a component of the EGF/Heregulin receptor signaling complex.Oncogene22:4348-4355.

      17. Wu M, Xu L, Zhai Z,Shu HB* (2003). SINK: a p65-interacting protein that negatively regulates NF-kB-dependent transcription. J Biol Chem278:27072-27079.

      18. Bin L, Xu L,Shu HB*(2003). TIRP: a novel TIR domain-containing adapter protein involved in toll/interleukin-1 receptor signaling. J Biol Chem27:24526-24532.

      19. Bin L, Nielson LD, Liu X, Mason RJ,Shu HB*(2003). Identification of UGRP1 and MARCO as a lung-specific ligand-receptor pair.J Immunol171:924-930.

      20. Zhang J, Xu LG, Han KJ,Shu HB*(2004). Identification of a ZU5 and death domain containing inhibitor of NF-kB.J Biol Chem279:17819-17825.

      21. Han KJ, Su X, Xu LG, Bin LH, Zhang J,Shu HB*(2004). Mechanisms of TRIF-induced ISRE and NF-kappa B activation and apoptosis pathways.J Biol Chem279:15652-15661.

      22. Huang J, Teng L, Li L, Liu T, Li L, Chen D, Xu LG, Zhai Z,Shu HB*(2004). ZNF216 is an A20-like and IKKgamma -interacting inhibitor of NF-kappa B activation.J Biol Chem279:16847-16853.

      23. Xu LG, Li LY,Shu HB* (2004). TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis.J Biol Chem279:17278-17282.

      24. Wu M, Xu LG, Su T, Huang J, Zhai Z,Shu HB*(2004). AMID is a p53-inducible gene down-regulated in tumors.Oncogene23:6815-6819.

      25. Li L, Bin LH, Li F, Liu Y, Chen D, Zhai Z,Shu HB*(2005). TRIP6 is a RIP2-associated common signaling component of multiple NF-kB activation pathways.J Cell Sci118:555-563.

      26. Xu LG, Wang YY, Han KJ, Li LY, Zhai Z,Shu HB*(2005). VISA is an adapter protein required for virus-triggered signaling.Mol Cell19:727-740.

      27. Huang J, Liu T, Chen D, Zhai Z,Shu HB*(2005). SIKE is an IKK-relative kinases-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways.EMBO J24:4018-4028.

      28. Zha J, Han K, Xu LG, Zhou Q, Chen D, Zhai Z,Shu HB*(2006). The Ret finger protein inhibits signaling mediated by the noncanonical and canonical IKK family members.J Immunol176:1072-1080.

      29. Tian Y, Zhang Y, Zhong B, Wang YY, Diao FC, Wang RP, Zhang M, Chen DY, Zhai ZH,Shu HB*(2007). RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation.J Biol Chem282:16776-16782.

      30. Diao F, Li S, Tian Y, Zhang M, Xu LG, Zhang Y, Wang RP, Chen D, Zhai Z, Zhong B, Tien P,Shu HB*(2007). Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxyacetone kinase.P Natl Acad Sci USA104:11706-11711.

      31. Zhang M, Tian Y, Wang RP, Gao D, Zhang Y, Diao FC, Chen DY, Zhai ZH,Shu HB*(2008). Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3.Cell Res18:1096-1014.

      32. Zhang B, Huang J, Li HL, Liu T, Wang YY, Waterman P, Mao AP, Xu LG, Zhai Z, Liu D, Marrack P,Shu HB*(2008). GIDE is a mitochondrial E3 ubiquitin ligase that induces apoptosis and slows growth.Cell Res18:900-910.

      33. Zhong B, Yang Y, Li S, Wang YY, Li Y, Diao F, Lei C, He X, Zhang L, Tien P,Shu HB*(2008). The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation.Immunity29:538-550.

      34. Zhong B, Zhang L, Lei Z, Li Y, Mao AP, Yang Y, Wang YY, Zhang XL,Shu HB*(2009). RNF5 negatively regulates virus-induced IRF3 activation via ubiquitination and degradation of MITA.Immunity30:397-407.

      35. Li Y, Li C, Xue P, Zhong B, Mao AP, Ran Y, Chen H, Wang YY, Yang F,Shu HB*(2009). ISG56 is a negative feedback regulator of virus-triggered signaling and cellular antiviral response.P Natl Acad Sci USA106:7945-7950.

      36. Wang YY, Liu LJ, Zhong B, Liu TT, Li Y, Yang Y, Ran Yong, Li S, Tien P,Shu HB*(2010). WDR5 is essential for assembly of the VISA-associated signaling complex and virus-triggered IRF3 and NF-kB activation.P Natl Acad Sci USA107:815-820.

      37. Li S, Zheng H, Mao AP, Zhong B, Li Y, Liu Y, Gao Y, Ran Y, Tien P,Shu, HB*(2010). Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated deubiquitination of TRAF3 and TRAF6.J Biol Chem285:4291-4297.

      38. Mao AP, Li S, Zhong B, Li Y, Yan J, Li Q, Teng C,Shu HB*(2010). Virus-triggered ubiquitination of TRAF3/6 by cIAP1/2 is essential for induction of interferon-beta (IFN-beta) and cellular antiviral response.J Biol Chem285:9470-9476.

      39. Han KJ, Yang Y, Xu LG,Shu HB*(2010). Analysis of a TIR-less splice variant of TRIF reveals an unexpected mechanism of TLR3-mediated signaling.J Biol Chem285:12543-12550.

      40. Chen R, Zhang L, Zhong B, Tan B, Liu Y,Shu HB*(2010).The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling.Cell Res20:802-811.

      41. Zhong B, Zhang Y, Tan B, Liu TT, Wang YY,Shu HB* (2010).The E3 ubiquitin ligase RNF5 targets virus-induced signaling adaptor for ubiquitination and degradation.J Immunol184:6249-6255.

      42. Lei CQ, Zhong B, Zhang Y, Zhang J,Shu HB*(2010). GSK3bregulates virus-triggered IRF3 activation and cellular antiviral response by promoting TBK1 activation.Immunity33:878-889.

      43. Li Q, Yan J, Mao AP, Li C, Ran Y,Shu HB*, Wang YY*(2011). Tripartite motif 8 (TRIM8) modulates TNFa- and IL-1b-triggered NF-kB activation by targeting TAK1 for K63-linked polyubiquitination.P Natl Acad Sci USA108:19341-19346.

      44. Ran Y, Liu TT, Zhou Q, Li S, Mao AP, Li Y, Liu LJ, Cheng JK,Shu HB*(2011).SENP2 negatively regulates cellular antiviral response by deSUMOylating IRF3 and conditioning it for ubiquitination and degradation.J Mol Cell Biol2:283-292.

      45. Liu Y, Song R, Gao Y, Li Y, Wang S, Liu HY, Wang Y, Hu YH,Shu HB*(2012).Protein kinase C-δ negatively regulates T cell receptor-induced NF-kB activation by inhibiting the assembly of CARMA1 signalosome.J Biol Chem287:20081-20087.

      46. He X, Li Y, Li C, Liu LJ, Zhang XD, Liu Y,Shu HB*(2012).USP2a negatively regulates IL-1β- and virus-induced NF-κB activation by deubiquitinating TRAF6.J Mol Cell Biol5:39-47.

      47. Zhang J, Hu MM, Wang YY,Shu HB*(2012).TRIM32 protein modulates type I interferon induction and cellular antiviral response by targeting MITA/STING protein for K63-linked ubiquitination.J Biol Chem287:28646-28655.

      48. Li Y, Chen R, Zhou Q, Xu Z, Li C, Wang S, Mao A, Zhang X, He W,Shu HB*(2012).LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection.P Natl Acad Sci USA109:11770-11775.

      49. Wang YY*, Ran Y,Shu HB*(2012).Linear ubiquitination of NEMO brakes the antiviral response.Cell Host Microbe12:129-131.

      50. Chen R, Li M, Zhang Y, Zhou Q,Shu HB*(2012).The E3 ubiquitin ligase MARCH8 negatively regulates IL-1β-induced NF-κB activation by targeting the IL1RAP coreceptor for ubiquitination and degradation.P Natl Acad Sci USA109:14128-14133.

      51. Zheng H, Li Q, Chen R, Zhang J, Ran Y, He X, Li S,Shu HB*(2012).Dual-specificity phosphatase 14 (DUSP14) negatively regulates TNF-aand IL-1-induced NF-κB activation by dephosphorylating the protein kinase TAK1.J Biol Chem288:819-825.

      52. Yang Y, Liao B, Wang S, Jin Y,Shu HB*, Wang YY*(2013). The E3 ubiquitin ligase WWP2 negatively regulates TLR3-mediated innate immune response by targeting TRIF for ubiquitination and degradation.PNAS110(13):5115-20.

      53. Li C, Wei J, Li Y, He X, Zhou Q, Yan J, Zhang J, Liu Y, Liu Y,Shu HB*(2013).Transmembrane protein 214 (TMEM214) mediates endoplasmic reticulum stress-induced caspase-4 activation and apoptosis.J Biol Chem288

      54. Lei CQ, Zhang Y, Xia T, Jiang LQ, Zhong B,Shu HB*(2013).FoxO1 Negatively Regulates Cellular Antiviral Response by Promoting Degradation of IRF3.J Biol Chem288:12596-12604.

      55. Chen H, Li Y, Zhang J, Ran Y, Wei J, Yang Y,Shu HB*(2013).RAVER1 is a coactivator of MDA5-mediated cellular antiviral response.J Mol Cell Biol5:111-119.

      56. Hu MM, Yang Q, Zhang J, Liu SM, Zhang Y, Lin H, Huang ZF, Wang YY, Zhang XD, Zhong B,Shu HB*(2013). TRIM38 inhibits TNFα- and IL-1β-triggered NF-κB activation by mediating lysosome-dependent degradation of TAB2/3.Proc. Natl. Acad. Sci. USA.111:1509-1514.

      57. Yan J, Li Q, Mao AP, Hu MM,Shu HB*(2013). TRIM4 modulates type I interferon induction and cellular antiviral response by targeting RIG-I for K63-linked ubiquitination.J. Mol. Cell Biol.6:154-163.

      58. Zhang Y, Lei CQ, Hu YH, Xia T, Li M, Zhong B,Shu HB*(2013). Kruppel-like Factor 6 Is a Co-activator of NF-κB That Mediates p65-dependent Transcription of Selected Downstream Genes.J. Biol. Chem289:12876-12885.

      59. Qin Y, Zhou MT, Hu MM ,Hu YH, Zhang J, Guo L, Zhong B,Shu HB*(2014). RNF26 temporally regulates virus-triggered type I interferon induction by two distinct mechanisms.Plos Pathog10:e1004358.

      60. Zhou Q, Lin H, Wang SY, Wang S, Ran Y, Liu Y, Ye W, Xiong XZ, Zhong B,Shu HB*,Wang YY*(2014). The ER-associated protein ZDHHC1 is a positive regulator of DNA virus-triggered, MITA/STING-dependent innate immune signaling.Cell Host Microbe16:450-61.

      61. Ran Y,Shu HB, Wang YY*(2014). MITA/STING: A central and multifaceted mediator in innate immune response.Cytokine & Growth F R25: 631-639.

      62. Shu HB*, Wang YY*(2014). Adding to the STING.Immunity41:871-3.

      63. Hu YH, Zhang Y, Jiang LQ, Wang S, Lei CQ, Sun MS,Shu HB, Liu Y*(2015).WDFY1 mediates TLR3/4 signaling by recruiting TRIF.EMBO REP16: 447-455

      64. Wei J, Lian H, Zhong B,Shu HB*(2015). Parafibromin Is a Component of IFN-γ-Triggered Signaling Pathways That Facilitates JAK1/2-Mediated Tyrosine Phosphorylation of STAT1.J Immunol195 : 2870-2878.

      65. Hu MM, Xie XQ, Yang Q, Liao CY, Ye W, Lin H,Shu HB*(2015).TRIM38 Negatively Regulates TLR3/4-Mediated Innate Immune and Inflammatory Responses by Two Sequential and Distinct Mechanisms.J Immunol195: 4415-4425.

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